By Michael Woodhead (via the Limbic)
A novel analgesic for osteoarthritis may offer better pain relief than current options but at the risk of more progressive disease and higher rates of total joint replacement.
Tanezumab, a monoclonal antibody blocking nerve growth factor, improved pain and physical function when compared to placebo in a trial of patients with moderate to severe OA of the knee or hip and inadequate response to standard analgesics.
But the 16-week randomised controlled trial involving 696 patients failed to dispel concerns from previous studies that tanezumab use was associated with high rates of joint damage and total joint replacements.
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